In 2014, four women vanish from Chillicothe, Ohio. When two are later found dead, fears of a serial killer mount when a fifth woman goes missing in 2015. Before police can fully investigate the fifth missing woman, another body is found.

While searching for the fifth missing woman, another body is found. With the help of an anonymous tip, police are onto a possible suspect within hours. The community digs in once again on the possibility of a serial killer.

When two bodies are found in the same area one year apart, people wonder if it could be a serial killer's dumping ground. Connections between two victims become clearer as one investigation is revisited.

In the final installment of The Vanishing Women, police chase down a terrifying new lead in a nearby town. Meanwhile, Jason McCrary, accused of murdering Timberly Claytor, goes to trial.