Carol Kenney enthusiastically begins her first day as an internal medicine intern, but has a rocky start when she disregards direct orders to help a patient; Carol meets Dr Frost, a senior attending physician who may be the ally Carol needs.

When an elderly patient's tests are inconclusive, Carol must find a way to work around hospital policy to take extra time to observe her. Meanwhile, Daniel is embarrassed when his fellow interns find out that he doesn't know how to draw blood.

While the other interns battle over who gets the patient with a fascinating and rare problem, Carol's standard, run-of-the-mill case turns out to be something more than it seems; Daniel makes a crucial mistake that gets Dr Jacobs' attention.

When Dr Jacobs collapses after running a marathon, Carol becomes her doctor and they clash over her course of treatment; Daniel and Lexie try to help Caleb conquer an old phobia.

When Carol has her first solo overnight shift at the hospital, Dr Frost's enthusiastic help and involvement become a little more than Carol bargained for; Jenny takes the interns to a bar to find dates.

The hospital is abuzz when Carol is assigned to care for a star college football player who has a broken rib; sparks continue to fly between Jenny and Daniel.